What are the Side Effects of Vitamin D Supplements?

side effects of Vitamin D supplements

Supplements are a great way to boost low Vitamin D levels, but its important to know about the potential side effects too. WUKA experts discuss the most common side effects of Vitamin D, along with tips on how to minimise them.

In this article we’ll be looking at:

The side effects of Vitamin D supplements

Vitamin D gummies vs tablets or capsules

How to minimise side effects of Vitamin D supplements. 

Common Side Effects of Vitamin D Supplements

Its always a good idea to speak to your GP or pharmacist before you start taking supplements, and to read the patient leaflet carefully.

For lots of us, the benefits of vitamin D supplements far outweigh any potential side effects, especially if we’re battling with a Vitamin D deficiency. And most people tolerate vitamin D supplements well, especially at recommended doses. 

That said, some individuals may experience:

Digestive Discomfort

You might notice nausea, stomach pain, or constipation when you start takng vitamin D supplements, especially if your doctor has prescribed a high-dose, or if you take them on an empty stomach.

If you're taking vitamin D3 formulations, try taking them with a meal containing some fat to improve absorption and to prevent digestive distress.

side effects of Vitamin D supplements

Headaches and Dizziness

Its not super common, but some people do experience headaches or light-headedness after starting vitamin D supplementation. These symptoms are usually mild and temporary, and will ease off after your body get used to taking them.

Changes in Appetite

Less commonly, you might notice changes in appetite, or unusual thirst when taking vitamin D supplements. This could be related to the vitamin's role in calcium metabolism and its effects on various hormones in the body.

Speak to your Gp if you’re concerned about any of these symptoms. 

Side Effects Specific to Different Forms

Some vitamin D supplements will have more side effects than others, which is worth knowing before you invest your time and money.

Vitamin D Gummies

Vitamin D gummies for adults are a really popular choice, thanks to their convenience and pleasant taste. However, it’s worth looking out for:

  • Sugar content: Many gummies contain added sugars, which could impact blood glucose levels or dental health if you take them regularly.
    side effects of Vitamin D supplements
  • Gelatin sensitivity: Some non-vegan gummies contain gelatin, which could cause tummy upset.

In general, most people tolerate Vitamin D gummies really well, and the benefits of taking this supplement over traditional tablets might be a game changer for you;

  • Gummies typically cause fewer digestive issues compared to traditional tablets because their soft, gel-like texture is easier for your body to break down
  • Gummies are great for anyone who struggles to swallow traditional supplements
  • Gummies have a more controlled release into your system, which often means less stomach discomfort or nausea that sometimes comes with tablets
  • Gummies are convenient - you can pop them in your bag without worrying about them getting crushed like tablets might, and there's no need for water to take them. 

While the gentle formulation of most vitamin D gummies means you're less likely to experience common side effects such as stomach upset, it’s still important to stick to the recommended dosage.

Liquid Drops and Oils

Potential side effects of liquid vitamin D supplements include:

  • Temporary throat irritation
  • Some people dislike the taste, particularly with oil-based formulations
  • Precise dosing can be challenging, increasing the risk of accidental overdose

Combination Products

If you’re using a combined Vitamin D3 and K2 supplement, be aware that vitamin K can interact with blood-thinning medications. Speak to your doctor before you start taking them to make sure they’re safe for you to use. 

side effects of vitamin d supplements

Serious Side Effects: When to Worry

Taking normal amounts of vitamin D supplements is very safe. Always follow the recommended daily amount on your vitamin D supplements, but be aware of the signs of potential Vitamin D toxicity, which include:

Hypercalcemia (Excessive Calcium in Blood)

Symptoms include:

  • Nausea and vomiting
  • Weakness
  • Frequent urination
  • Bone pain
  • Kidney problems (including kidney stones)

Cardiovascular Effects

In severe cases, excessive vitamin D can contribute to:

  • Irregular heartbeat
  • Blood vessel calcification
  • High blood pressur

These serious effects are extremely rare when you follow recommended dosage guidelines, and they typically only occur with prolonged high-dose supplementation (usually above 10,000 IU daily for extended periods).

Are Vitamin D supplements right for me?

Some groups of people might not find Vitamin D supplements work for them. Always speak to your GP or pharmacist if you’re not sure, and follow guidance carefully.

side effects of vitamin d supplements

Vegans and Vitamin D

Most vitamin D3 comes from animal sources (usually lanolin from sheep's wool), but vegan vitamin D supplements derived from lichen are increasingly available. WUKA Cycle Care Vitamin D gummies are vegan friendly, and suitable for anyone on a plant-based diet.

Vitamin D in pregnancy

Pregnant women need to get enough vitamin D for themselves and for the baby, and should follow dosage recommendations carefully. Moderate supplementation is generally considered safe and beneficial, but its always a good idea to speak to your doctor to check before you start taking them.

Vitamin D and medical conditions

There are some medical conditions that might need special consideration when it comes to vitamin D supplementation:

  • Kidney disease
  • High blood calcium levels
  • Sarcoidosis
  • Tuberculosis
  • Lymphoma
  • Histoplasmosis

These conditions can affect how your body processes vitamin D, potentially increasing the risk of side effects even at normal doses.

side effects of vitamin d supplements

Minimising side effects of Vitamin D supplements 

If you experience mild side effects from vitamin D supplements, this tips might help:

1. Take supplements with Food

Taking vitamin D with a meal that contains some fat can improve absorption and reduce stomach discomfort.

2. Build up your dosage gradually 

Start with a lower dose and gradually increase to your target amount, giving your body time to adjust.

3. Consider alternative forms

If you experience digestive issues with one form of vitamin D, try another. For example, if traditional pills cause stomach upset, natural vitamin D supplements or vitamin D in gummies might be better tolerated.

4. Divide your dose

Taking smaller amounts twice daily rather than one large dose may reduce side effects.

5. Monitor Vitamin D levels

Regular blood tests to check your vitamin D levels can help ensure you're taking an appropriate amount—not too little or too much.

When to see a doctor

Always seek medical advice if you experience

  • Persistent digestive issues after starting supplementation
  • Symptoms of high calcium levels (excessive thirst, frequent urination, fatigue)
  • Kidney pain or stones
  • Unusual heart rhythms or palpitations
  • Unexpected weight loss
  • Confusion or disorientation

These symptoms could indicate that your dosage needs adjustment or that you might have an underlying condition affecting how your body responds to vitamin D.

The Bottom Line: Benefits vs. Risks

For most people, the health benefits of maintaining adequate vitamin D levels significantly outweigh the potential for side effects. The key is finding the right dose and formulation for your individual needs.

Whether you choose traditional vitamin D3 supplements, vitamin D gummies for adults, or specialized products like vitamin D3 with K2, working with a healthcare provider to monitor your levels can help you maximize benefits while minimizing risks.

Remember, supplements are meant to complement a healthy lifestyle that includes some safe sun exposure and vitamin D-rich foods—not replace them entirely. By taking a balanced approach to vitamin D intake, you can support your overall health while keeping side effects at bay.